Scale bars for HES are 100 and 50 μm for immunofluorescence panels. The rectum expresses keratin 8 (Krt8) (red). A population of keratin 17 (Krt17) expressing cells (white) shown by immunofluorescence is present at the anorectal TZ (n = 55 independent experiments from 58 mice and n = 3 independent experiments from two independent human samples). Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during homeostasis and repair.Ī population of basal Keratin 17+ cells at the anorectal junction contributes to the anal epithelium during normal homeostasisĪ Human and mouse anorectal TZ are histologically (HES) and molecularly similar. Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, by using in vivo lineage tracing, single-cell transcriptomics, computational modeling and a three-dimensional organoid culture system of transition zone cells, we identify a population of Krt17+ basal cells with multipotent properties at the squamo-columnar anorectal junction that maintain a squamous epithelium during normal homeostasis and can participate in the repair of a glandular epithelium following tissue injury. However, their roles during tissue regeneration in normal and injured state remain unknown. The mere fact that transition zone cells can merge different architecture with separate functions implies for a unique plasticity that these cells must display in steady state. These transition zones contain cells expressing markers of adult stem cells that can be the target of early transformation. What prefix do the vm's serial number begin with?At numerous locations of the body, transition zones are localized at the crossroad between two types of epithelium and are frequently associated with neoplasia involving both type of tissues. I just cant see it clearly enough to read it by the time I zoom into it. It does have the info on the backside of the head stock. I know what this is, trouble is, how much does the missing logo affect the resale value?Īlso, if I did get it, are the correct logos available somewhere? I mean its a nice looking guitar and all, I'd just like to know if it's a deal breaker, as even if I can find and replace the correct logo's, mating the finish color on the rest of the neck wouldn't be so easy. #2, and probably what got me off my game is, The head stock has been sanded clean. Now, any other time I'd be all about working a deal, but its aprox 100 mile round trip #1. he claims he bought it used the way it sits. It has the vintage slotted tuners and the pup covers have Duncan Designed on them, they are the cream or parchment color. What prefix do the VM's serial number begin with?Īs always any info would be greatly appreciated. It does have the S/N on the backside of the head stock. I think I know what this is, trouble is, how much does the missing logo affect the resale value?Īlso, if I did get it, are the correct logos available somewhere? I mean its a nice looking guitar and all, I'd just like to know if it's a deal breaker, as even if I can find and replace the correct logo's, matching the finish color on the rest of the neck wouldn't be so easy. I think he believes it's just a squier strat like any other. I, at this point, do not think he is aware of what model it is. And says as far as he knows it s all original. I've found a vintage modified strat with the full maple neck and tobacco sunburst with white pick guard.
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